| 2005 |
| Originalarbeiten |
| Jordan A, Scholz R, Maier-Hauff K, van Landeghem FK, Waldoefner N,
Teichgraeber U, Pinkernelle J, Bruhn H, Neumann F, Thiesen B, von
Deimling A, Felix R. The effect of thermotherapy using magnetic nanoparticles on rat malignant glioma. Neurooncol. 2006 May;78(1):7-14. Epub 2005 Nov 29. |
| Wemmert S, Ketter R, Rahnenfuhrer J, Beerenwinkel N, Strowitzki M,
Feiden W, Hartmann C, Lengauer T, Stockhammer F, Zang KD, Meese E,
Steudel WI, von Deimling A, Urbschat S. Patients with high-grade gliomas harboring deletions of chromosomes 9p and 10q benefit from temozolomide treatment. Neoplasia. 2005 Oct;7(10):883-93 |
| Holtkamp N, Afanasieva A, Elstner A, van Landeghem FK, Konneker M, Kuhn SA, Kettenmann H, von Deimling A. Brain slice invasion model reveals genes differentially regulated in glioma invasion. Biochem Biophys Res Commun. 2005 Nov 4;336(4):1227-33. |
| de Stahl TD, Hartmann C, de Bustos C, Piotrowski A, Benetkiewicz M,
Mantripragada KK, Tykwinski T, von Deimling A, Dumanski JP. Chromosome 22 tiling-path array-CGH analysis identifies germ-line- and tumor-specific aberrations in patients with glioblastoma multiforme. Genes Chromosomes Cancer. 2005 Oct;44(2):161-9. |
| Hartmann C, Bartels G, Gehlhaar C, Holtkamp N, von Deimling A. PIK3CA mutations in glioblastoma multiforme. Acta Neuropathol (Berl). 2005 Jun;109(6):639-42. Epub 2005 May 28. |
| Rahnenfuhrer J, Beerenwinkel N, Schulz WA, Hartmann C, von Deimling A, Wullich B, Lengauer T. Estimating cancer survival and clinical outcome based on genetic tumor progression scores. Bioinformatics. 2005 May 15;21(10):2438-46. Epub 2005 Feb 10. |
| Übersichtsartikel |
| Hartmann C, von Deimling A. Oligodendrogliomas: impact of molecular genetics on treatment. Neurol India. 2005 Jun;53(2):140-8. |
| Hartmann C, Mueller W, Lass U, Kamel-Reid S, von Deimling A.
Molecular genetic analysis of oligodendroglial tumors. J Neuropathol Exp Neurol. 2005 Jan;64(1):10-4. |
| Buchkapitel |
| 2006 |
| Originalarbeiten |
| Maier-Hauff K, Rothe R, Scholz R, Gneveckow U, Wust P, Thiesen B,
Feussner A, von Deimling A, Waldoefner N, Felix R, Jordan A. Intracranial Thermotherapy using Magnetic Nanoparticles Combined with External Beam Radiotherapy: Results of a Feasibility Study on Patients with Glioblastoma Multiforme. J Neurooncol. 2006 Jun 14. |
| Hartmann C, Devermann L, Gehlhaar C, Holtkamp N, von Deimling A. PIK3CA mutations in oligodendroglial tumours. Neuropathol Appl Neurobiol. 2006 Apr;32(2):209-12. |
| Tews B, Felsberg J, Hartmann C, Kunitz A, Hahn M, Toedt G, Neben K,
Hummerich L, von Deimling A, Reifenberger G, Lichter P. Identification of novel oligodendroglioma-associated candidate tumor suppressor genes in 1p36 and 19q13 using microarray-based expression profiling. Int J Cancer. 2006 Aug 15;119(4):792-800. |
| 2007 |
| Originalarbeiten |
| Blankenburg F, van Landeghem FK, Plotkin M, Henze G, von Deimling A, Driever PH. Occurrence of a spinal anaplastic pilocytic astrocytoma and a supratentorial PNET in an adolescent. J Pediatr Hematol Oncol. 2007 Dec;29(12):832-5. |
| Weller M, Berger H, Hartmann C, Schramm J, Westphal M, Simon M, Goldbrunner R, Krex D, Steinbach JP, Ostertag CB, Loeffler M, Pietsch T, von Deimling A; German Glioma Network. Combined 1p/19q loss in oligodendroglial tumors: predictive or prognostic biomarker? Clin Cancer Res. 2007 Dec 1;13(23):6933-7. |
| Holtkamp N, Atallah I, Okuducu AF, Mucha J, Hartmann C, Mautner VF, Friedrich RE, Mawrin C, von Deimling A. MMP-13 and p53 in the progression of malignant peripheral nerve sheath tumors. Neoplasia. 2007 Aug;9(8):671-7. |
| Krex D, Klink B, Hartmann C, von Deimling A, Pietsch T, Simon M, Sabel M, Steinbach JP, Heese O, Reifenberger G, Weller M, Schackert G; German Glioma Network. Long-term survival with glioblastoma multiforme. Brain. 2007 Oct;130(Pt 10):2596-606. Epub 2007 Sep 4. |
| Kunitz A, Wolter M, van den Boom J, Felsberg J, Tews B, Hahn M, Benner A, Sabel M, Lichter P, Reifenberger G, von Deimling A, Hartmann C. DNA hypermethylation and aberrant expression of the EMP3 gene at 19q13.3 in Human Gliomas. Brain Pathol. 2007 Oct;17(4):363-70. Epub 2007 Jul 4. |
| Holtkamp N, Ziegenhagen N, Malzer E, Hartmann C, Giese A, von Deimling A. Characterization of the amplicon on chromosomal segment 4q12 in glioblastoma multiforme. Neuro Oncol. 2007 Jul;9(3):291-7. Epub 2007 May 15 |
| Mueller W, Schneider GH, Hoffmann KT, Zschenderlein R, von Deimling A. Granulomatous tissue response in germinoma, a diagnostic pitfall in endoscopic biopsy. 2007 Apr;27(2):127-32. |
| Stockhammer F, Thomale UW, Plotkin M, Hartmann C, Von Deimling A. Association between fluorine-18-labeled fluorodeoxyglucose uptake and 1p and 19q loss of heterozygosity in World Health Organization Grade II gliomas. J Neurosurg. 2007 Apr;106(4):633-7. |
| van Landeghem FK, Weiss T, Oehmichen M, von Deimling A. Cellular localization of pituitary adenylate cyclase-activating peptide (PACAP) following traumatic brain injury in humans. Acta Neuropathol. 2007 Jun;113(6):683-93. Epub 2007 Mar 13. |
| Elstner A, Holtkamp N, von Deimling A. Involvement of Hif-1 in desferrioxamine-induced invasion of glioblastoma cells. Clin Exp Metastasis. 2007;24(1):57-66. Epub 2007 Mar 15. |
| Tews B, Roerig P, Hartmann C, Hahn M, Felsberg J, Blaschke B, Sabel M, Kunitz A, Toedt G, Neben K, Benner A, von Deimling A, Reifenberger G, Lichter P. Hypermethylation and transcriptional downregulation of the CITED4 gene at 1p34.2 in oligodendroglial tumours with allelic losses on 1p and 19q. Oncogene. 2007 Jul 26;26(34):5010-6. Epub 2007 Feb 19. |
| Rickert CH, Schwering EM, Siebers J, Hartmann C, von Deimling A, Paulus W. Chromosomal imbalances and NF2 mutational analysis in a series of 10 spinal nerve sheath myxomas. Histopathology. 2007 Jan;50(2):252-7. |
| Hagel C, Zils U, Peiper M, Kluwe L, Gotthard S, Friedrich RE, Zurakowski D, von Deimling A, Mautner VF. Histopathology and clinical outcome of NF1-associated vs. sporadic malignant peripheral nerve sheath tumors. J Neurooncol. 2007 Apr;82(2):187-92. Epub 2006 Nov 17. |
| Stockhammer F, Thomale UW, Plotkin M, Hartmann C, Von Deimling A. Association between fluorine-18-labeled fluorodeoxyglucose uptake and 1p and 19q loss of heterozygosity in World Health Organization Grade II gliomas. J Neurosurg. 2007 Apr;106(4):633-7. |
| Michaelis M, Cinatl J, Anand P, Rothweiler F, Kotchetkov R, von Deimling A, Doerr HW, Shogen K, Cinatl J Jr. Onconase induces caspase-independent cell death in chemoresistant neuroblastoma cells. Cancer Lett. 2007 May 18;250(1):107-16. Epub 2006 Nov 3. |
| Mueller W, Nutt CL, Ehrich M, Riemenschneider MJ, von Deimling A, van den Boom D, Louis DN. Downregulation of RUNX3 and TES by hypermethylation in glioblastoma. Oncogene. 2007 Jan 25;26(4):583-93. Epub 2006 Aug 14. |
| Maier-Hauff K, Rothe R, Scholz R, Gneveckow U, Wust P, Thiesen B, Feussner A, von Deimling A, Waldoefner N, Felix R, Jordan A. Intracranial thermotherapy using magnetic nanoparticles combined with external beam radiotherapy: results of a feasibility study on patients with glioblastoma multiforme. J Neurooncol. 2007 Jan;81(1):53-60. Epub 2006 Jun 14. |
| Simon M, Bostrom J, Hartmann C. Molecular genetics of meningiomas. From basic research to potential clinical applications. Histopathology. 2007 Jan;50(2):252-7. |
| 2008 |
| Originalarbeiten |
| Pfister S, Remke M, Castoldi M, Bai AH, Muckenthaler MU, Kulozik A, von Deimling A, Pscherer A, Lichter P, Korshunov A Novel genomic amplification targeting the microRNA cluster at 19q13.42 in a pediatric embryonal tumor with abundant neuropil and true rosettes. Acta Neuropathol 2008 Dec 5 (Epub ahead of print) |
| Milde T, Pfister S, Korshunov A, Deubzer HE, Oehme I, Ernst A, Starzinski-Powitz A, Seitz A, Lichter P, von Deimling A, Witt O Stepwise accumulation of distinct genomic aberrations in a patient with progressively metastasizing ependymoma. Genes Chromosomes Cancer 2008 Nov 21 (Epub ahead of print) |
| Siegelin MD, Reuss DE, Habel A, Herold-Mende C, von Deimling A The flavonoid kaempferol sensitizes human glioma cells to TRAIL-mediated apoptosis by proteasomal degradation of survivin. Mol Cancer Ther 2008 Nov; 7(11): 3566-74. |
| Balss J, Meyer J, Mueller W, Korshunov A, Hartmann C, von Deimling A Analysis of the IDH 1 codon 132 mutation in brain tumors. Acta Neuropathol 2008 Dec; 116(6): 597-602, Epub 2008 Nov 5. |
| Siegelin MD, Reuss DE, Habel A, Rami A, von Deimling Quercetin promotes degradation of survivin and thereby enhances death-receptor mediated apoptosis in glioma cells. Neuro Oncol 2008 Oct 29 (Epub ahead of print) |
| van Landeghem FK, Maier-Hauff K, Jordan A, Hoffmann KT, Gneveckow U, Scholz r, Thiesen B, Brück W, von Deimling A Post-mortem studies in glioblastoma patients treated with thermotherapy using magnetic nanoparticles. Biomaterials 2008 Oct 9 (Epub ahead of print) |
| Korshunov A, Benner A, Remke M, Lichter P, von Deimling A, Pfister S Accumulation of genomic aberrations during clinical progression of medulloblastoma. Acta Neuropathol 2008 Oct; 116(4): 383-90, Epub 2008 Aug 15 |
| Holtkamp N, Malzer E, Zietsch J, Okuducu AF, Mucha J, Mawrin C, Mautner V, Schildhaus HU, von Deimling A EGFR and erbB2 in malignant peripheres nerve sheath tumors and implications for targeted therapy. Neuro Oncol 2008 Jul 23 (Epub ahead of print) |
| Lorente A, Mueller W, Urdangarin E, Lázcoz P, Lass U, von Deimling A, Castresana JS RASSF1A, BLU, NoRE1A, PTEN and MGMT Expression and Promoter Methylation in Gliomas and Glioma Cell Lines and Evidence of Deregulated Expression of de novo DNMTs. Brain Pathol 2008 Jun 25 (Epub ahead of print) |
| Hartmann C, Wiestler O.D. Die neue WHO-Hirntumor-Klassifikation aus dem Jahr 2007. Brainstorm. 2008 Ausgabe 1: 22-25 |
| 2005 |
| Originalarbeiten |
| Droske M, Meyer B, Rumpf M, Schaller C. An adaptive level set method for interactive segmentation of intracranial tumors. Neurol Res 27:363-370, 2005 |
| Majores M, Schick V, Engels G, Fassunke J, Elger CE, Schramm J, Blümcke I, Becker AJ Mutational and immunohistochemical analysis of ezrin-, radixin-, moesin (ERM) molecules in epilepsy-associated glioneuronal lesions. Acta Neuropathol (Berl). 2005 Dec;110(6):537-46. |
| Wurzel M, Schaller C, Simon M, Deutsch A. Brain cancer invasion of brain tissue: guided by a prepattern. J Theoretical Med 2005;6:21-31 |
| Sahin A, Velten M, Pietsch T, Knüfermann P, Okuducu AF, Hahne JC, Wernert N Inactivation of Ets 1 transcription factor by a specific decoy strategy reduces rat C6 glioma cell proliferation and mmp-9 expression. Int J Mol Med 2005;15:771-776 |
| Waha A, Guntner S, Huang TH, Yan PS, Arslan B, Pietsch T, Wiestler OD, Waha A Epigenetic silencing of the protocadherin family member PCDH-gamma-A11 in astrocytomas. Neoplasia 2005;7:193-199 |
| Übersichtsartikel |
| Hatzikirou B, Schaller C, Simon M, Wurzel M, Swanson KR, Deutsch A. Mathematical modelling of glioma tumor development: a review. Math Models Meth Appl Sci , 2005;15:1779-1794 |
| Neuloh G, Schramm J. What surgeon wins, and what surgeon loses when applying intraoperative neurophysiologic monitoring? Acta Neurochir (Wien). 2005 Aug;147(8):811-3 |
| Buchkapitel |
| 2006 |
| Originalarbeiten |
| Kral T, Kurthen M, Urbach H, Schramm J, Meyer B. Stimulation mapping via implanted grid electrodes prior to surgery for gliomas in highly eloquent cortex. Neurosurgery. 2006;58(1 Suppl): ONS36-43; discussion ONS3 |
| Simon M, Voß D, Park-Simon TW, Mahlberg R, Köster G Role of p16 and p14ARF in radio- and chemosensitivity of malignant gliomas. Oncol Rep. 2006 Jul;16(1):127-32 |
| Simon M, Ludwig M, Fimmers R, Mahlberg R, Müller-Erkwoh A, Köster G,
Schramm J (2006) A variant of the CHEK2 gene as a prognostic marker in glioblastoma multiforme Neurosurgery, 2006 Nov;59(5):1078-85 |
| Semmler A, Simon M, Moskau S, Linnebank M The methionine synthase polymorphism c2756A>G alters susceptibility to glioblastoma multiforme. Cancer Epidemiol Biomarkers Prev 2006 Nov;15(11):2314-6. |
| Felsberg J, Yan PS, Huang TH, Milde U, Schramm J, Wiestler OD, Reifenberger G, Pietsch T, Waha A DNA methylation and allelic losses on chromosome arm 14q in oligodendroglial tumours. Neuropathol Appl Neurobiol. 2006 Oct;32(5):517-24. |
| Übersichtsartikel |
| Becker AJ, Blumcke I, Urbach H, Hans V, Majores M. Molecular neuropathology of epilepsy-associated glioneuronal malformations. J Neuropathol Exp Neurol. 2006 Feb;65(2):99-108 |
| Schramm J, Blümcke I, Ostertag CB, Schlegel U, Simon M, Lutterbach J Low-grade gliomas - current concepts. Zentralbl Neurochir. 2006 May;67(2):55-66 |
| Buchkapitel |
| 2007 |
| Originalarbeiten |
| Schick V, Majores M, Fassunke J, Engels G, Simon M, Elger CE, Becker AJ Mutational and expression analysis of CDK1, cyclinA2 and cyclinB1 in epilepsy-associated glioneuronal lesions. Neuropathol Appl Neurobiol, 33(2):152-162, 2007 |
| Weber RG, Hoischen A, Ehrler M, Zipper P, Kaulich K, Blaschke B, Becker AJ, Weber-Mangal S, Jauch A, Radlwimmer B, Schramm J, Wiestler OD, Lichter P, Reifenberger G Frequent loss of chromosome 9, homozygous CDKN2A/p14ARF/CDKN2B deletion and low TSC1 mRNA expression in pleomorphic xanthoastrocytomas. Oncogene 26(7):1088-97, 2007 |
| Mikeska T, Bock C, El-Maarri O, Hübner A, Ehrentraut D, Schramm J, Felsberg J, Kahl P, Büttner R, Pietsch T, Waha A Optimization of quantitative MGMT promoter methylation analysis using pyrosequencing and combined bisulfite restriction analysis. J Mol Diagn. 2007 Jul;9(3):368-81 |
| Neuloh G, Pechstein U, Schramm J Motor tract monitoring during insular glioma surgery. J Neurosurg. 2007 Apr;106(4):582-92. |
| Schramm J, Aliashkevich AF Surgery for temporal mediobasal tumors: experience based on a series of 235 patients. Neurosurgery. 2007 Feb;60(2):285-94 |
| Trost D, Ehrler M, Fimmers R, Felsberg J, Sabel MC, Kirsch L, Schramm J, Wiestler OD, Reifenberger G, Weber RG Identification of genomic aberrations associated with shorter overall survival in patients with oligodendroglial tumors. Int J Cancer. 2007 Jun 1;120(11):2368-76. |
| Stüer C, Vilz B, Majores M, Becker A, Schramm J, Simon M Frequent recurrence and progression in pilocytic astrocytoma in adults. Cancer. 2007;110(12): 2799-808 |
| Krex D, Klink B, Hartmann C, von Deimling A, Pietsch T, Simon M, Sabel M, Steinbach J, Heese O, Reifenberger G, Weller M, Schackert G, German Glioma Network Long-term survival with glioblastoma multiforme. Brain. 2007 Oct;130(Pt 10):2596-606 |
| Weller M, Berger H, Hartmann C, Schramm J, Westphal M, Simon M, Tonn JC, Schackert G, Steinbach JP, Ostertag CB, Löffler M, Pietsch T, von Deimling A, for the German Glioma Network Combined 1p/19q loss in oligodendroglial tumors: predictive or prognostic biomarker? Clin Cancer Res. 2007;13(23): 6933-7 |
| Majores M, Niehusmann P, von Lehe M, Blümcke I, Urbach H Angiocentric neuroepithelial tumor mimicking Ammon's horn sclerosis--case report. Clin Neuropathol. 2007;26(6): 311-6 |
| Neuloh G, Simon M, Schramm J Stroke prevention during surgery for deep-seated gliomas. Neurophysiol Clin. 2007;37(6): 383-9 |
| Übersichtsartikel |
| Schick V, Majores M, Koch A, Elger CE, Schramm J, Urbach H, Becker AJ Alterations of phosphatidylinositol 3-kinase pathway components in epilepsy associated glioneuronal lesions. Epilepsia. 2007;48 Suppl 5:65-73. |
| Buchkapitel |
| 2008 |
| Originalarbeiten |
| Linnebank M, Semmler A, Moskau S, Simon M The methylenetetrahydrofolate reductase variant c.677C>T (A222V) influences survival of patients with glioblastoma multiforme. Neuro Oncol. 2008 Aug;10(4):548-52. Epub 2008 May 22. |
| Hoischen A, Ehrler M, Fassunke J, Simon M, Baudis M, Landwehr C, Radlwimmer B, Lichter P, Schramm J, Becker AJ, Weber RG Comprehensive characterization of genomic aberrations in gangliogliomas by comparative genomic hybridization (CGH), array-based CGH and interphase-FISH. Brain Pathol. 2008 Jul;18(3):326-37. Epub 2008 Mar 26 |
Majores M, von Lehe M, Fassunke J, Schramm J, Becker AJ, Simon M |
| Simon M, Neuloh G, von Lehe M, Meyer B, Schramm J Insular gliomas: the case for surgical management. Cancer, Epub 2008 November 5. |
D. Basanta, M. Simon, H. Hatzikirou and A. Deutsch |
Snoei J, Urbach H, Engels G, Fassunke J, von Lehe M, Becker AJ, Majores M. |
Schramm J, Aliashkevich AF |
Wolff JE, Kramm C, Kortmann RD, Pietsch T, Rutkowski S, Jorch N, Gnekow A, Driever PH. |
Stummer W, Reulen HJ, Meinel T, Pichlmeier U, Schumacher W, Tonn JC, Rohde V, Oppel F, Turowski B, Woiciechowsky C, Franz K, Pietsch T |
Pfister S, Janzarik WG, Remke M, Ernst A, Werft W, Becker N, Toedt G,
Wittmann A, Kratz C, Olbrich H, Ahmadi R, Thieme B, Joos S, Radlwimmer B, Kulozik
A, Pietsch T, Herold-Mende C, Gnekow A, Reifenberger G, Korshunov A, Scheurlen W, Omran H, Lichter P. |
Wolff JE, Classen CF, Wagner S, Kortmann RD, Palla SL, Pietsch T, Kühl J, Gnekow A, Kramm CM. |
Thal D, Xavier CP, Rosentreter A, Linder S, Friedrichs B, Waha A, Pietsch T, Stumpf M, Noegel A, Clemen C. |
Vladimirova V, Waha A, Lückerath K, Pesheva P, Probstmeier R. |
Fassunke J, Majores M, Tresch A, Niehusmann P, Grote A, Schoch S, Becker AJ. |
Glas M, Rasch K, Wiewrodt D, Weller M, Herrlinger U. |
Glas M, Stuplich M, Tschampa H, Urbach H, Rasch K, Herrlinger U. |
Glas M, Happold C, Rieger J, Wiewrodt D, Bähr O, Steinbach JP, Wick W, Kortmann RD, Reifenberger G, Weller M, Herrlinger U. |
Glas M, Hundsberger T, Stuplich M, Wiewrodt D, Kurzwelly D, Nguyen-Huu B, Rasch K, Herrlinger U. |
Benesch M, Windelberg M, Sauseng W, Witt V, Fleischhack G, Lackner H, Gadner H, Bode U, Urban C. |
| 2009 |
| Originalarbeiten |
| Lugnier C, Majores M, Fassunke J, Pernhorst K, Niehusmann P, Simon M, Nellist M, Schoch S, Becker A. Hamartin variants that are frequent in focal dysplasias and cortical tubers have reduced tuberin binding and aberrant subcellular distribution in vitro J Neuropathol Exp Neurol. 2009 Oct;68(10):1136-46. |
| Weller M, Felsberg J, Hartmann C, Berger H, Steinbach JP, Schramm J, Westphal M, Schackert G, Simon M, Tonn JC, Heese O, Krex D, Nikkhah G, Pietsch T, Wiestler O, Reifenberger G, von Deimling A, Loeffler M. Molecular predictors of progression-free and overall survival in patients with newly diagnosed glioblastoma: a prospective translational study of the German Glioma Network. Neuropathol Exp Neurol. 2009 Oct;68(10):1136-46. |
| Shete S, Hosking FJ, Robertson LB, Dobbins SE, Sanson M, Malmer B, Simon M, Marie Y, Boisselier B, Delattre JY, Hoang-Xuan K, El Hallani S, Idbaih A, Zelenika D, Andersson U, Henriksson R, Bergenheim AT, Feychting M, Lönn S, Ahlbom A, Schramm J, Linnebank M, Hemminki K, Kumar R, Hepworth SJ, Price A, Armstrong G, Liu Y, Gu X, Yu R, Lau C, Schoemaker M, Muir K, Swerdlow A, Lathrop M, Bondy M, Houlston RS.Genome-wide association study identifies five susceptibility loci for glioma. Nat Genet. 2009 Aug;41(8):899-904. Epub 2009 Jul 5. |
| Simon M, Neuloh G, von Lehe M, Meyer B, Schramm J. Insular gliomas: the case for surgical management. J Neurosurg. 2009 Apr;110(4):685-95. |
| von Lehe M, Schramm J. Gliomas of the cingulate gyrus: surgical management and functional outcome. Neurosurg Focus. 2009 Aug;27(2):E9. |
| Campos AR, Clusmann H, von Lehe M, Niehusmann P, Becker AJ, Schramm J, Urbach H. Simple and complex dysembryoplastic neuroepithelial tumors (DNT) variants: clinical profile, MRI, and histopathology. Neuroradiology. 2009 Jul;51(7):433-43. Epub 2009 Feb 26. Review. |
| Kurzwelly D, Glas M, Roth P, Weimann E, Lohner H, Waha A, Schabet M, Reifenberger G, Weller M, Herrlinger U. Primary CNS lymphoma in the elderly: temozolomide therapy and MGMT status. J Neurooncol. 2009 Oct 20. [Epub ahead of print] |
| Weiler M, Hartmann C, Wiewrodt D, Herrlinger U, Gorlia T, Bähr O, Meyermann R, Bamberg M, Tatagiba M, von Deimling A, Weller M, Wick W. Chemoradiotherapy of Newly Diagnosed Glioblastoma with Intensified Temozolomide. Int J Radiat Oncol Biol Phys. 2009 Oct 14. [Epub ahead of print] |
| Herrlinger U, Glantz M, Schlegel U, Gisselbrecht C, Cavalli F. Should intra-cerebrospinal fluid prophylaxis be part of initial therapy for patients with non-Hodgkin lymphoma: what we know, and how we can find out more. Semin Oncol. 2009 Aug;36(4 Suppl 2):S25-34. Review. |
| Bähr O, Herrlinger U, Weller M, Steinbach JP. Very late relapses in glioblastoma long-term survivors. J Neurol. 2009 Oct;256(10):1756-8. Epub 2009 May 12. |
| Glas M, Hundsberger T, Stuplich M, Wiewrodt D, Kurzwelly D, Nguyen-Huu B, Rasch K, Herrlinger U. Nimustine (ACNU) plus teniposide (VM26) in recurrent glioblastoma. Oncology. 2009;76(3):184-9. Epub 2009 Feb 13. |
| Glas M, Happold C, Rieger J, Wiewrodt D, Bähr O, Steinbach JP, Wick W, Kortmann RD, Reifenberger G, Weller M, Herrlinger U. Long-term survival of patients with glioblastoma treated with radiotherapy and lomustine plus temozolomide. J Clin Oncol. 2009 Mar 10;27(8):1257-61. Epub 2009 Feb 2. |
| Wismeth C, Dudel C, Pascher C, Ramm P, Pietsch T, Hirschmann B, Reinert C, Proescholdt M, Rümmele P, Schuierer G, Bogdahn U, Hau P. Transcranial electro-hyperthermia combined with alkylating chemotherapy in patients with relapsed high-grade gliomas: phase I clinical results. J Neurooncol. 2009 Dec 24. [Epub ahead of print] |
| Wolff JE, Driever PH, Erdlenbruch B, Kortmann RD, Rutkowski S, Pietsch T, Parker C, Metz MW, Gnekow A, Kramm CM. Intensive chemotherapy improves survival in pediatric high-grade glioma after gross total resection: results of the HIT-GBM-C protocol. Cancer. 2009 Dec 2. [Epub ahead of print] |
| Nabavi A, Thurm H, Zountsas B, Pietsch T, Lanfermann H, Pichlmeier U, Mehdorn M; 5-ALA Recurrent Glioma Study Group. Five-aminolevulinic acid for fluorescence-guided resection of recurrent malignant gliomas: a phase ii study. Neurosurgery. 2009 Dec;65(6):1070-6; discussion 1076-7. |
| von Hoff K, Hartmann W, von Bueren AO, Gerber NU, Grotzer MA, Pietsch T, Rutkowski S. Large cell/anaplastic medulloblastoma: Outcome according to myc status, histopathological, and clinical risk factors. Pediatr Blood Cancer. 2009 Nov 11. [Epub ahead of print] |
| Kordes U, Gesk S, Frühwald MC, Graf N, Leuschner I, Hasselblatt M, Jeibmann A, Oyen F, Peters O, Pietsch T, Siebert R, Schneppenheim R Clinical and molecular features in patients with atypical teratoid rhabdoid tumor or malignant rhabdoid tumor. Genes Chromosomes Cancer. 2010 Feb;49(2):176-81. |
| Wick W, Hartmann C, Engel C, Stoffels M, Felsberg J, Stockhammer F, Sabel MC, Koeppen S, Ketter R, Meyermann R, Rapp M, Meisner C, Kortmann RD, Pietsch T, Wiestler OD, Ernemann U, Bamberg M, Reifenberger G, von Deimling A, Weller M. NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with procarbazine, lomustine, and vincristine or temozolomide. J Clin Oncol. 2009 Dec 10;27(35):5874-80. Epub 2009 Nov 9. |
| Karremann M, Rausche U, Fleischhack G, Nathrath M, Pietsch T, Kramm CM, Wolff JE. Clinical and epidemiological characteristics of pediatric gliosarcomas. J Neurooncol. 2009 Oct 6. [Epub ahead of print] |
| Beier CP, Schmid C, Gorlia T, Kleinletzenberger C, Beier D, Grauer O, Steinbrecher A, Hirschmann B, Brawanski A, Dietmaier C, Jauch-Worley T, Kölbl O, Pietsch T, Proescholdt M, Rümmele P, Muigg A, Stockhammer G, Hegi M, Bogdahn U, Hau P. RNOP-09: pegylated liposomal doxorubicine and prolonged temozolomide in addition to radiotherapy in newly diagnosed glioblastoma--a phase II study. BMC Cancer. 2009 Sep 2;9:308. |
| Vladimirova V, Mikeska T, Waha A, Soerensen N, Xu J, Reynolds PC, Pietsch T. Aberrant methylation and reduced expression of LHX9 in malignant gliomas of childhood. Neoplasia. 2009 Jul;11(7):700-11. |
| Gaiser T, Waha A, Moessler F, Bruckner T, Pietsch T, von Deimling A. Comparison of automated silver enhanced in situ hybridization and fluorescence in situ hybridization for evaluation of epidermal growth factor receptor status in human glioblastomas. Mod Pathol. 2009 Sep;22(9):1263-71. Epub 2009 Jun 12 |
| Lueth M, Wronski L, Giese A, Kirschner-Schwabe R, Pietsch T, von Deimling A, Henze G, Kurtz A, Driever PH. Somatic mitochondrial mutations in pilocytic astrocytoma. Cancer Genet Cytogenet. 2009 Jul;192(1):30-5. |
| Garrè ML, Cama A, Bagnasco F, Morana G, Giangaspero F, Brisigotti M, Gambini C, Forni M, Rossi A, Haupt R, Nozza P, Barra S, Piatelli G, Viglizzo G, Capra V, Bruno W, Pastorino L, Massimino M, Tumolo M, Fidani P, Dallorso S, Schumacher RF, Milanaccio C, Pietsch T. Medulloblastoma variants: age-dependent occurrence and relation to Gorlin syndrome--a new clinical perspective. Clin Cancer Res. 2009 Apr 1;15(7):2463-71. Epub 2009 Mar 10. |
| von Hoff K, Hinkes B, Gerber NU, Deinlein F, Mittler U, Urban C, Benesch M, Warmuth-Metz M, Soerensen N, Zwiener I, Goette H, Schlegel PG, Pietsch T, Kortmann RD, Kuehl J, Rutkowski S. Long-term outcome and clinical prognostic factors in children with medulloblastoma treated in the prospective randomised multicentre trial HIT'91. Eur J Cancer. 2009 May;45(7):1209-17. Epub 2009 Feb 26. |
| Sahin A, Vercamer C, Kaminski A, Fuchs T, Florin A, Hahne JC, Mattot V, Pourtier-Manzanedo A, Pietsch T, Fafeur V, Wernert N. Dominant-negative inhibition of Ets 1 suppresses tumor growth, invasion and migration in rat C6 glioma cells and reveals differentially expressed Ets 1 target genes. Int J Oncol. 2009 Feb;34(2):377-89. |
| Marx JA, Röhrborn AJ, Koelsch BU, Fischer C, Herrmann T, Pietsch T, Rajewsky MF, Kindler-Röhrborn A. Ablation of T cell immunity differentially influences tumor risk in inbred BD rat strains. Cancer Immunol Immunother. 2009 Aug;58(8):1287-95. Epub 2009 Jan 13. |
| Karremann M, Butenhoff S, Rausche U, Pietsch T, Wolff JE, Kramm CM. Pediatric giant cell glioblastoma: New insights into a rare tumor entity. Neuro Oncol. 2009 Jun;11(3):323-9. Epub 2008 Dec 2. |
| Karremann M, Pietsch T, Janssen G, Kramm CM, Wolff JE. Anaplastic ganglioglioma in children. J Neurooncol. 2009 Apr;92(2):157-63. Epub 2008 Nov 29. |
| Rutkowski S, Gerber NU, von Hoff K, Gnekow A, Bode U, Graf N, Berthold F, Henze G, Wolff JE, Warmuth-Metz M, Soerensen N, Emser A, Ottensmeier H, Deinlein F, Schlegel PG, Kortmann RD, Pietsch T, Kuehl J; German Pediatric Brain Tumor Study Group. Treatment of early childhood medulloblastoma by postoperative chemotherapy and deferred radiotherapy. Neuro Oncol. 2009 Apr;11(2):201-10. Epub 2008 Sep 25. |
| Snoei J, Urbach H, Engels G, Fassunke J, von Lehe M, Becker AJ, Majores M. Genetic alterations of protein-o-mannosyltransferase-1 in glioneuronal and glial brain tumors with subarachnoid spread. Neuropathology. 2009 Apr;29(2):116-24. Epub 2008 Jul 20. |
| Nagane M, Nozue K, Shimizu S, Waha A, Miyazaki H, Kurita H, Homori M, Fujioka Y, Shiokawa Y. Prolonged and severe thrombocytopenia with pancytopenia induced by radiation-combined temozolomide therapy in a patient with newly diagnosed glioblastoma--analysis of O6-methylguanine-DNA methyltransferase status. J Neurooncol. 2009 Apr;92(2):227-32. Epub 2008 Nov 27. |
| Buchkapitel |
Simon M, Kristof RA, Schramm J (2009) Glioneural tumors. In: Tonn J, Westphal M, Grossmann S, Rutka JT(eds.): Neuro-Oncology of CNS-Tumors, 2nd ed. Springer-Verlag, Heidelberg, |
| Reviews |
| Simon M, Schramm J.: Surgical management of intracranial gliomas. Recent Results Cancer Res. 2009;171:105-24 |
| Kurzwelly D, Herrlinger U, Simon M (2009): Seizures in patients with low grade gliomas – incidence, pathogenesis, surgical management, and pharmacotherapy. Adv Tech Stand Neurosurg 35: 82-111 |
| 2005 |
| Originalarbeiten |
| Krafft C, Sobottka SB, Schackert G, Salzer R. Near infrared Raman spectroscopic mapping of native brain tissue and intracranial tumors. Analyst. 2005 Jul;130(7):1070-7. Epub 2005 May 24. |
| Martinez R, Schackert HK, Kirsch M, Paulus W, Joos S, Schackert G. Comparative genetic analysis of metachronous anaplastic oligoastrocytomas with extended recurrence-free interval. J Neurooncol. 2005 Apr;72(2):95-102. |
| Kirsch M, Weigel P, Pinzer T, Carroll RS, Black PM, Schackert HK, Schackert G. Therapy of hematogenous melanoma brain metastases with endostatin. Clin Cancer Res. 2005 Feb 1;11(3):1259-67 |
| Martinez R, Schackert HK, Appelt H, Plaschke J, Baretton G, Schackert G. Low-level microsatellite instability phenotype in sporadic glioblastoma multiforme. J Cancer Res Clin Oncol. 2005 Feb;131(2):87-93. Epub 2004 Oct 16. |
| Weigle B, Ebner R, Temme A, Schwind S, Schmitz M, Kiessling A, Rieger MA, Schackert G, Schackert HK, Rieber EP. Highly specific overexpression of the transcription factor SOX11 in human malignant gliomas. Oncol Rep. 2005 Jan;13(1):139-44. |
| Elam C, Hesson L, Vos MD, Eckfeld K, Ellis CA, Bell A, Krex D, Birrer MJ, Latif F, Clark GJ. RRP22 is a farnesylated, nucleolar, Ras-related protein with tumor suppressor potential. Cancer Res. 2005 Apr 15;65(8):3117-25. |
| Temme A, Herzig E, Weigle B, Morgenroth A, Schmitz M, Kiessling A, Rieger MA, Schackert HK, Rieber EP Inhibition of malignant glioma cell growth by a survivin mutant retrovirus. Hum Gene Ther 2005;16:209-222 |
| Übersichtsartikel |
| Buchkapitel |
| 2006 |
| Originalarbeiten |
| Benger W, Bartsch H, Choumilina A, Hege HC, Kitzler H, Werner A Visualization of Brain Neuronal Structures for Tumor Detection via Diffusion Tensor MRI. Int J Neurosci 2006;116:461-514 |
| Krafft C, Thummler K, Sobottka SB, Schackert G, Salzer R Classification of malignant gliomas by infrared spectroscopy and linear discriminant analysis. Biopolymers 2006;82:301-305 |
| Martinez R, Schackert G, Esteller M Hypermethylation of the proapoptotic gene TMS1/ASC: prognostic importance in glioblastoma multiforme. J Neurooncol 2006; Oct 18; [Epub ahead of print] |
| Martinez R, Schackert G, Yaya-Tur R, Rojas-Marcos I, Herman JG, Esteller M Frequent hypermethylation of the DNA repair gene MGMT in long-term survivors of glioblastoma multiforme. J Neurooncol 2006; Dec 13; [Epub ahead of print] |
| McLaughlin N, Annabi B, Bouzeghrane M, Temme A, Bahary JP, Moumdjian R, Beliveau R The Survivin-mediated radioresistant phenotype of glioblastomas is regulated by RhoA and inhibited by the green tea polyphenol (-)-epigallocatechin-3-gallate. Brain Res 2006;1071:1-9 |
| Schmitz M, Wehner R, Stevanovic S, Kiessling A, Rieger MA, Temme A, Bachmann M, Rieber EP, Weigle B Identification of a naturally processed T cell epitope derived from the glioma-associated protein SOX11. Cancer Lett in press |
| Sergeeva O, Uhlemann F, Schackert G, Hergeth C, Morgenstern U, Steinmeier R Integration of intraoperative 3D-ultrasound in a commercial navigation system. Zentralbl Neurochir 2006;67:197-203 |
| Stummer W, Pichlmeier U, Meinel T, Wiestler OD, Zanella F, Reulen HJ; ALA-Glioma Study Group Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. Lancet Oncol 2006;7:392-401 |
| 2007 |
| Originalarbeiten |
| Martinez R, Schackert G. Epigenetic aberrations in malignant gliomas: an open door leading to better understanding and treatment. Epigenetics. 2007 Jul-Sep;2(3):147-50. Epub 2007 Sep 15. Review. |
| Kirsch M, Allende R, Black P, Schackert G. Endogenous growth inhibition of angiogenesis in brain tumors. Cancer Metastasis Rev. 2007 Dec;26(3-4):469-79. |
| Krex D, Klink B, Hartmann C, von Deimling A, Pietsch T, Simon M, Sabel M, Steinbach JP, Heese O, Reifenberger G, Weller M, Schackert G; German Glioma Network. Long-term survival with glioblastoma multiforme. Brain. 2007 Oct;130(Pt 10):2596-606. Epub 2007 Sep 4. Review. |
| Krafft C, Kirsch M, Beleites C, Schackert G, Salzer R. Methodology for fiber-optic Raman mapping and FTIR imaging of metastases in mouse brains. Anal Bioanal Chem. 2007 Oct;389(4):1133-42. Epub 2007 Jul 17. |
| Martinez R, Roggendorf W, Baretton G, Klein R, Toedt G, Lichter P, Schackert G, Joos S. Cytogenetic and molecular genetic analyses of giant cell glioblastoma multiforme reveal distinct profiles in giant cell and non-giant cell subpopulations. Cancer Genet Cytogenet. 2007 May;175(1):26-34. |
| Schmitz M, Temme A, Senner V, Ebner R, Schwind S, Stevanovic S, Wehner R, Schackert G, Schackert HK, Fussel M, Bachmann M, Rieber EP, Weigle B. Identification of SOX2 as a novel glioma-associated antigen and potential target for T cell-based immunotherapy. Br J Cancer. 2007 Apr 23;96(8):1293-301. Epub 2007 Mar 20. Erratum in: Br J Cancer. 2007 Jun 18;96(12):1928. |
| Martinez R, Setien F, Voelter C, Casado S, Quesada MP, Schackert G, Esteller M CpG island promoter hypermethylation of the pro-apoptotic gene caspase-8 is a common hallmark of relapsed glioblastoma multiforme. Carcinogenesis. 2007 Jun;28(6):1264-8. Epub 2007 Feb 1. |
| Martinez R, Schackert G, Yaya-Tur R, Rojas-Marcos I, Herman JG, Esteller M. Frequent hypermethylation of the DNA repair gene MGMT in long-term survivors of glioblastoma multiforme. J Neurooncol. 2007 May;83(1):91-3. Epub 2006 Dec 13 |
| Krafft C, Sobottka SB, Geiger KD, Schackert G, Salzer R. Classification of malignant gliomas by infrared spectroscopic imaging and linear discriminant analysis. Anal Bioanal Chem. 2007 Mar;387(5):1669-77. Epub 2006 Nov 14. |
| Temme A, Rodriguez JA, Hendruschk S, Günes S, Weigle B, Schäkel K, Schmitz M, Bachmann M, Schackert G, Rieber EP. Nuclear localization of Survivin renders HeLa tumor cells more sensitive to apoptosis by induction of p53 and Bax. Cancer Lett. 2007 Jun 8;250(2):177-93. Epub 2006 Nov 7. |
| Martinez R, Schackert G, Esteller M. Hypermethylation of the proapoptotic gene TMS1/ASC: prognostic importance in glioblastoma multiforme. J Neurooncol. 2007 Apr;82(2):133-9. Epub 2006 Oct 18. |
| 2008 |
| Originalarbeiten |
| Kirsch M, Mörz M, Pinzer T, Schackert HK, Schackert G. Frequent loss of the CDKN2C (p18INK4c) gene product in pituitary adenomas. Genes Chromosomes Cancer. 2009 Feb;48(2):143-54. |
| Hesson LB, Krex D, Latif F.. Epigenetic markers in human gliomas: prospects for therapeutic intervention. Expert Rev Neurother. 2008 Oct;8(10):1475-96. Review |
| Pels H, Juergens A, Glasmacher A, Schulz H, Engert A, Linnebank M, Schackert G, Reichmann H, Kroschinsky F, Vogt-Schaden M, Egerer G, Bode U, Schaller C, Lamprecht M, Hau P, Deckert M, Fimmers R, Bangard C, Schmidt-Wolf IG, Schlegel U. Early relapses in primary CNS lymphoma after response to polychemotherapy without intraventricular treatment: results of a phase II study. J Neurooncol. 2009 Feb;91(3):299-305. Epub 2008 Oct 18. |
| Sobottka SB, Geiger KD, Salzer R, Schackert G, Krafft C. Suitability of infrared spectroscopic imaging as an intraoperative tool in cerebral glioma surgery. Anal Bioanal Chem. 2009 Jan;393(1):187-95. Epub 2008 Oct 16. |
| Steiner G, Küchler S, Hermann A, Koch E, Salzer R, Schackert G, Kirsch M. Rapid and label-free classification of human glioma cells by infrared spectroscopic imaging. Cytometry A. 2008 Dec;73A(12):1158-64. |
| Schaich M, Kestel L, Pfirrmann M, Robel K, Illmer T, Kramer M, Dill C, Ehninger G, Schackert G, Krex D. A MDR1 (ABCB1) gene single nucleotide polymorphism predicts outcome of temozolomide treatment in glioblastoma patients. Ann Oncol. 2009 Jan;20(1):175-81. Epub 2008 Aug 7. |
| Pichlmeier U, Bink A, Schackert G, Stummer W; ALA Glioma Study Group Resection and survival in glioblastoma multiforme: an RTOG recursive partitioning analysis of ALA study patients. Neuro Oncol. 2008 Dec;10(6):1025-34. Epub 2008 Jul 30. |
| Stummer W, Reulen HJ, Meinel T, Pichlmeier U, Schumacher W, Tonn JC, Rohde V, Oppel F, Turowski B, Woiciechowsky C, Franz K, Pietsch T; ALA-Glioma Study Group. Extent of resection and survival in glioblastoma multiforme: identification of and adjustment for bias. Neurosurgery. 2008 Mar;62(3):564-76; discussion 564-76. |
| Huttner HB, Janich P, Köhrmann M, Jászai J, Siebzehnrubl F, Blümcke I, Suttorp M, Gahr M, Kuhnt D, Nimsky C, Krex D, Schackert G, Löwenbrück K, Reichmann H, Jüttler E, Hacke W, Schellinger PD, Schwab S, Wilsch-Bräuninger M, Marzesco AM, Corbeil D. The stem cell marker prominin-1/CD133 on membrane particles in human cerebrospinal fluid offers novel approaches for studying central nervous system disease. Stem Cells. 2008 Mar;26(3):698-705. Epub 2007 Dec 20. |
| 2005 |
| Originalarbeiten |
| Möllemann M, Wolter M, Felsberg J, Collins VP, Reifenberger G Frequent hypermethylation and low expression of the MGMT gene in oligodendroglial tumors. Int J Cancer 2005 113:379-85. |
| Floeth FW, Pauleit D, Wittsack HJ, Langen KJ, Reifenberger G, Hamacher K, Messing-Jünger M, Zilles K, Weber F, Stummer W, Steiger HJ, Woebker G, Müller HW, Sabel M Multimodal metabolic imaging of cerebral gliomas: Positron emission tomography with (18)F]-fluoroethyl-l-tyrosine and magnetic resonance spectroscopy. J Neurosurg 2005 102: 318-327. |
| Pauleit D, Floeth FW, Hamacher K, Riemenschneider MJ, Reifenberger G, Müller HW, Zilles K, Coenen HH, Langen HJ Positron-emission tomography with O-(2-[18F]fluoroethyl)-L-tyrosine combined with magnetic resonance imaging improves the diagnostic assessment of cerebral gliomas. Brain 2005 128(Pt 3):678-87. |
| Knobbe CB, Trampe-Kieslich A, Reifenberger G Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas. Neuropathol Appl Neurobiol, 2005;31:486-490 |
| Roerig P, Nessling M, Radlwimmer B, Joos S, Wrobel G, Schwänen C , Reifenberger G, Lichter P Molecular classification of human gliomas using matrix-based comparative genomic hybridization. Int J Cancer. 2005 Oct 20;117(1):95-103. |
| Langen KJ, Hamacher K, Pauleit D, Floeth FW, Stoffels G, Bauer D, Reifenberger G, Zilles K, Coenen HH Evaluation of new 18F-labeled amino acids for brain PET. Anat Embryol (Berl) 2005;210:455-461 |
| Übersichtsartikel |
| Buchkapitel |
| 2006 |
| Originalarbeiten |
| Distelmaier F, Fahsold R, Reifenberger G, Messing-Juenger M, Schaper J, Schneider DT, Göbel U, Mayatepek E, Rosenbaum T Fatal glioblastoma multiforme in a patient with neurofibromatosis type I: the dilemma of systematic medical follow-up. Childs Nervous System 2006 Aug 29; [Epub ahead of print] |
| Felsberg J, Yan PS, Huang THM, Milde U, Schramm J, Wiestler OD, Reifenberger G, Pietsch T, Waha A DNA methylation and allelic losses on chromosome arm 14q in oligodendroglial tumors. Neuropathol App Neurobiol 2006;32:517-524 |
| Floeth FW, Pauleit D, Sabel M, Reifenberger G, Stoffels G, Stummer W, Rommel F, Hamacher K, Langen KJ 18F-FET PET differentiation of ring-enhancing brain lesions. J Nucl Med 2006;47:776-782 |
| Floeth FW, Pauleit D, Sabel M, Stoffels G, Reifenberger G, Riemenschneider MJ, Jansen P, Hamacher K, Coenen HH, Stummer W, Steiger HJ, Langen KJ Prediction of prognosis in low grade glioma patients with magnetic resonance imaging and positron emission tomography using F-18-fluoroethyltyrosine. J Nucl Med 2007; (in press) |
| Herrlinger U, Rieger J, Koch D, Loeser S, Blaschke B, Kortmann RD, Steinbach JP, Hundsberger T, Wick W, Meyermann R, Sommer C, Bamberg M, Reifenberger G, Weller M Phase I/II trial (UKT-03) of CCNU plus temozolomide chemotherapy in addition to radiotherapy as first-line therapy for glioblastoma. J Clin Oncol 2006;24:4412-4417 |
| Sharma MK, Mansur DB, Reifenberger G, Perry A, Aldape KD, Emnett RJ, Loeser S, Watson MA, Nagarajan R, Gutmann DH Distinct genetic signatures among pilocytic astrocytomas relate to their brain region origin. Cancer Res 2007; (in press) |
| Tews B, Felsberg J, Hartmann C, Kunitz A, Hahn M, Toedt G, Neben K, Hummerich L, von Deimling A, Reifenberger G, Lichter P Identification of novel oligodendroglioma-associated candidate tumor suppressor genes in 1p36 and 19q13 using microarray-based expression profiling. Int J Cancer 2006;119:792-800 |
| Tews B, Roerig P, Hartmann C, Hahn M, Felsberg J, Blaschke B, Sabel M, Hoffmann A, Toedt G, Neben K, Benner A, von Deimling A, Reifenberger G, Lichter P Hypermethylation and transcriptional downregulation of the CITED4 gene at 1p34.2 2 in oligodendroglial tumors with allelic losses on 1p and 19q. Oncogene 2007; (in press) |
| Trost D, Ehrler M, Fimmers R, Felsberg J, Sabel MC, Kirsch L, Schramm J, Wiestler OD, Reifenberger G, Weber RG Identification of genomic aberrations associated with shorter survival of patients with oligodendroglial tumors. Int J Cancer 2007 (in press) |
| van den Boom J, Wolter M, Blaschke B, Knobbe CB, Reifenberger G Identification of novel genes associated with astrocytoma progression using suppression subtractive hybridization and real-time reverse transcription-polymerase chain reaction. Int J Cancer119:2330-2338 |
| Weber RG, Hoischen A, Ehrler M, Zipper P, Kaulich K, Blaschke B, Becker AJ, Weber S, Jauch A, Radlwimmer B, Schramm J,Wiestler OD, Lichter P, Reifenberger G Frequent loss of chromosome 9, homozygous CDKN2A/p14ARF/CDKN2B deletion and low TSC1 mRNA expression in pleomorphic xanthoastrocytomas. Oncogene 2006 Aug 7 [Epup ahead of print] |
| Zoriy MV, Dehnhardt M, Reifenberger G, Zilles K, Becker JS Imaging of CU, Zn, Pb and U in human brain tumor sections by laser ablation inductively coupled mass spectrometry. Int J Mass Spectrom 2006; 257:27-33 |
| Übersichtsartikel |
| Buchkapitel |
| 2007 |
| Originalarbeiten |
| Weber RG, Hoischen A, Ehrler M, Zipper P, Kaulich K, Blaschke B, Becker AJ, Weber S, Jauch A, Radlwimmer B, Schramm J,Wiestler OD, Lichter P, Reifenberger G. Frequent loss of chromosome 9, homozygous CDKN2A/p14ARF/CDKN2B deletion and low TSC1 mRNA expression in pleomorphic xanthoastrocytomas. Oncogene 2007; 26:1088-97. |
| Floeth FW, Pauleit D, Sabel M, Stoffels G, Reifenberger G, Riemenschneider MJ, Jansen P, Hamacher K, Coenen HH, Stummer W, Steiger HJ, Langen KJ. Prediction of prognosis in low grade glioma patients with magnetic resonance imaging and positron emission tomography using F-18-fluoroethyltyrosine. J Nucl Med 2007; 48:519-527. |
| Sharma MK, Mansur DB, Reifenberger G, Perry A, Aldape KD, Emnett RJ, Loeser S, Watson MA, Nagarajan R, Gutmann DH. Distinct genetic signatures among pilocytic astrocytomas relate to their brain region origin. Cancer Res 2007, 67:890-900. |
| Tews B, Roerig P, Hartmann C, Hahn M, Felsberg J, Blaschke B, Sabel M, Hoffmann A, Toedt G, Neben K, Benner A, von Deimling A, Reifenberger G, Lichter P. Hypermethylation and transcriptional downregulation of the CITED4 gene at 1p34.2 in oligodendroglial tumors with allelic losses on 1p and 19q. Oncogene 2007, 6(34):5010-6. |
| Trost D, Ehrler M, Fimmers R, Felsberg J, Sabel MC, Kirsch L, Schramm J, Wiestler OD, Reifenberger G, Weber RG. Identification of genomic aberrations associated with shorter survival of patients with oligodendroglial tumors. Int J Cancer 2007, 120:2368-2376. |
| Kros JM, Gorlia T, Kouwenhoven MC, Zheng PP, Collins VP, Figarella-Branger D, Giangaspero F, Giannini C, Mokhtari K, Mørk SJ, Paetau A, Reifenberger G, van den Bent, MJ. Panel review of anaplastic oligodendroglioma from EORTC trial 26951: assessment of consensus in diagnosis, influence of 1p/19q loss and correlations with outcome. J Neuropathol Exp Neurol 2007, 66:545-551. |
| Wick A, Felsberg J, Steinbach JP, Herrlinger U, Platten M, Blaschke B, Meyermann R, Reifenberger G, Weller M, Wick W. Phase II trial of temozolomide in an one week on/one week off regimen in recurrent glioma. J Clin Oncol 2007: 3357-3361. |
| Kunitz A, Wolter M, van den Boom J, Felsberg J, Tews B, Hahn M, Benner A, Sabel M, Lichter P, Reifenberger G, von Deimling A, Hartmann C. DNA hypermethylation and aberrant expression of the EMP3 gene at 19q13.3 in human gliomas. Brain Pathol 2007, 17(4):363-70. |
| Krex D, Klink B, Hartmann C, von Deimling A, Pietsch T, Simon M, Sabel M, Steinbach J, Heese O, Reifenberger G, Weller M, Schackert G. Clinical and molecular parameters associated with long-term survival of glioblastoma multiforme. Brain 2007, 130(Pt 10):2596-606. |
| Boulay JL, Miserez AR, Zweifel C, Sivasankaran B, Kana V, Ghaffari A, Luyken C, Sabel M, Zerrouqi A, Wasner M, Meir EV, Tolnay M, Reifenberger G, Merlo A. Loss of NOTCH2 Positively Predicts Survival in Subgroups of Human Glial Brain Tumors. PLoS ONE. 2007 Jun 27;2:e576. |
| Schlierf B, Friedrich RP, Roerig P, Felsberg J, Reifenberger G, Wegner M. Expression of SoxE and SoxD genes in human gliomas. Neuropathol Appl Neurobiol 2007, 33(6):621-30. |
| Mikeska T, Bock C, El-Maarri O, Hubner A, Ehrentraut D, Schramm J, Felsberg J, Kahl P, Buttner R, Pietsch T, Waha A. Optimization of quantitative MGMT promoter methylation analysis using pyrosequencing and combined bisulfite restriction analysis. J Mol Diagn. 2007, 9(3):368-81. |
| Grasbon-Frodl EM, Kreth FW, Ruiter M, Bise K, Felsberg J, Reifenberger G, Tonn JC, Kretzschmar HA. Intratumoral homogeneity of promoter hypermethylation of the MGMT gene as detected in serial stereotactic specimens from anaplastic astrocytomas and glioblastomas. Int J Cancer 2007; 121(11):2458-64. |
| Dehnhardt M, Zoriy MV, Kahn Z, Reifenberger G, Ekström TJ, Becker JS, Zilles K, Bauer A. Element distribution is altered in a zone surrounding human glioblastoma multiforme. J Trace Elem Med Biol 2007, available online 22 October 2007. |
| Riemenschneider MJ, Reifenberger J, Reifenberger G. Frequent biallelic inactivation and transcriptional silencing of the DIRAS3 gene at 1p31 in oligodendroglial tumors with 1p loss. Int J Cancer 2008 (in press). |
| Topoel M, Loosten PHLJ, Knobbe CB, Afink GB, Zotz RB, Steegers-Theunissen PM, Reifenberger G, van Zoelen EJJ (2007) Haplotype-specific expression of the human PDGFRA gene correlates with the risk of glioblastoma tumors. Int J Cancer 2008 (in press). |
| Buchkapitel |
| Reifenberger G, Kros JM, Louis DN, Collins VP. Oligodendroglioma. In Louis DN, Ohgaki H, Weistler OD, Cavanee WK (Eds.). WHO Classification of Tumours of the Central Nervous System. IARC, Lyon, 2007, pp 54-59. |
| Reifenberger G, Kros JM, Louis DN, Collins VP Anaplastic oligodendroglioma. In Louis DN, Ohgaki H, Weistler OD, Cavanee WK (Eds.). WHO Classification of Tumours of the Central Nervous System. IARC, Lyon, 2007, pp 60-62. |
| von Deimling A, Reifenberger G, Kros JM, Louis DN, Collins VP. Oligoastrocytoma. . In Louis DN, Ohgaki H, Weistler OD, Cavanee WK (Eds.). WHO Classification of Tumours of the Central Nervous System. IARC, Lyon, 2007, pp 63-65. |
| von Deimling A, Reifenberger G, Kros JM, Louis DN, Collins VP. Anaplastic oligoastrocytoma. In Louis DN, Ohgaki H, Weistler OD, Cavanee WK (Eds.). WHO Classification of Tumours of the Central Nervous System. IARC, Lyon, 2007, pp 66-67. |
| Riemenschneider MJ, Reifenberger G. Gene expression profiling of gliomas - improving the understanding of glioma biology and paving the way to molecular classification. In Müller HW (Ed.) Neural Degeneration and Repair: Gene Expression Profiling, Proteomics, Glycomics and Systems Biology. Wiley-VCH 2008 (in press). |
| 2008 |
| Originalarbeiten |
| Riemenschneider MJ, Reifenberger J, Reifenberger G. Frequent biallelic inactivation and transcriptional silencing of the DIRAS3 gene at 1p31 in oligodendroglial tumors with 1p loss. Int J Cancer 2008 Jun 1;122(11):2503-10. |
| Topoel M, Loosten PHLJ, Knobbe CB, Afink GB, Zotz RB, Steegers-Theunissen PM, Reifenberger G, van Zoelen EJJ. Haplotype-specific expression of the human PDGFRA gene correlates with the risk of glioblastoma tumors. Int J Cancer 2008 Jul 15;123(2):322-9. |
| Preusser M, Janzer RC, Felsberg J, Reifenberger G, Stupp R, Gorlia T, Marosi C, Heinzl H, Hainfellner JA, Hegi M. Anti-MGMT immunohistochemistry in glioblastoma multiforme: observer variability and lack of association with patient survival impede its use as clinical biomarker - A translational research project of the European Organization for Research and Treatment of Cancer Brain Tumour Group. Brain Pathol 2008 Oct;18(4):520-32. |
| Pfister S, Janzarik WG, Remke M, Ernst A, Werft W, Becker N, Toedt G, Wittmann A, Kratz C, Olbrich H, Ahmadi R, Thieme B, Joos S, Radlwimmer B, Kulozik A, Pietsch T, Herold-Mende C, Gnekow A, Reifenberger G, Korshunov A, Scheurlen W, Omran H, Lichter P. BRAF gene duplication constitutes a novel mechanism of MAPK pathway activation in low-grade astrocytomas. J Clin Invest 2008 May 1;118(5):1739-1749. |
| Schittenhelm J, Reifenberger G, Ritz R, Nägele T, Weller M, Pantazis G, Capper D, Beschorner R, Meyermann R, Mittelbronn M. Primary anaplastic ganglioglioma with a small-cell glioblastoma component. Clin Neuropathol 2008; 27(2):91-95. |
| Dehnhardt M, Zoriy MV, Kahn Z, Reifenberger G, Ekström TJ, Becker JS, Zilles K, Bauer A. Element distribution is altered in a zone surrounding human glioblastoma multiforme. J Trace Elem Med Biol 2008 22:17-23. |
| Tepel M, Roerig P, Wolter M, Gutmann DH, Perry A, Reifenberger G, Riemenschneider MJ. Frequent promoter hypermethylation and transcriptional down-regulation of the NDRG2 gene at 14q11.2 in primary glioblastomas. Int J Cancer 2008 Nov 1;123(9):2080-6. |
| Rickert CH, Riemenschneider MJ, Schachenmayr W, Richter HP, Bockhorn J, Reifenberger G, Paulus W. Glioblastoma with adipocyte-like differntiation – histological and molecular characterization of a rare glioblastoma differentiation pattern. Brain Pathol 2008 Aug 6. [Epub ahead of print]. |
| Beier D, Röhrl S, Pillai DR, Schwarz S, Kunz-Schughart L, Leukel P, Proescholdt M, Brawanski A, Bogdahn U, Trampe-Kieslich A, Giebel B, Wischhusen J, Reifenberger G, Hau P, Beier CP. Temozolomide preferentially depletes cancer stem cells in glioblastoma. Cancer Res 2008; 68(14):5706-15. |
| Pfister S, Remke M, Benner A, Mendrzyk F, Toedt G, Felsberg J, Wittmann A, Devens F, Joos S, Kulozik A, Reifenberger G, Rutkowski S, Wiestler OD, Radlwimmer B, Scheurlen W, Lichter P, Korshunov A. Molecular risk stratification of pediatric medulloblastoma based on genomic aberrations. J Clin Oncol (in press). |
| Grund K, Ahmadi R, Jung F, Funke V, Gdynia G, Benner A, Sykora J, Walczak H, Joos S, Felsberg J, Reifenberger G, Wiestler OD, Herold-Mende C, Roth W. Troglitazone-mediated sensitization to TRAIL-induced apoptosis is regulated by proteasome-dependent degradation of FLIP and ERK1/2-dependent phosphorylation of BAD. Cancer Biology & Therapy, (in press). |
| Warnke C, Lanzman RS, Klink B, Schellhammer F, Reifenberger G, Methner A (2008) Diffuse leptomeningeal astrocytoma in a patient suffering from infantile epilepsy. Arch Neurol (in press). |
| Riemenschneider MJ, Beseoglu K, Hänggi D, Reifenberger G. Prostate adenocarcinoma metastasis in the pituitary gland. Arch Neurol (in press). |
| Glas M, Happold C, Rieger J, Wiewrodt D, Bähr O, Steinbach JP, Wick W, Kortmann RD, Reifenberger G, Weller M, Herrlinger U. Long-term survival of glioblastoma patients treated with radiotherapy and lomustine plus temozolomide. J Trace Elem Med Biol 2008 22:17-23. |
| Übersichtsartikel |
| Schackert G, Felsberg J, Reifenberger G, Schlegel U Hirnmetastasen: Neuropathologie – Allgemeine Therapiemaßnahmen – Operative Therapie. Der Onkologe 2008; 14:233-245. |
| Riemenschneider MJ, Reifenberger G. Molecular neuropathology of gliomas. Int J Mol Sci (in press). |
| Buchkapitel |
| Riemenschneider MJ, Reifenberger G. Histology and Molecular Genetics, in Primary Optic Nerve Sheath Meningioma in: Series: Medical Radiology, Subseries: Radiation Oncology, edited by Branislav Jeremic and Susanne Pitz, Springer Verlag, Heidelberg, 2008, pp55-66. |
| Riemenschneider MJ, Reifenberger G. Meningioma in Encyclopedia of Molecular Mechanisms of Disease, edited by Florian Lang, Springer Verlag, Heidelberg (Erscheinungsdatum Juli 2008).. |
| Riemenschneider MJ, Reifenberger G. Gene expression profiling of gliomas – improving the understanding of glioma biology and paving the way to molecular classification, in: Neural Degeneration and Repair: Gene Expression Profiling, Proteomics and Systems Biology, edited by Hans Werner Müller, Wiley-VCH, Weinheim (Erscheinungsdatum Februar 2008). |
| Riemenschneider MJ, Reifenberger G. Astrocytic tumors, in Brain Tumors, Series: Recent Results in Cancer Research, Vol 171, edited by Andreas von Deimling, Springer Verlag, Heidelberg (Erscheinungsdatum März 2009). |
2009 |
| Originalarbeiten |
| Weller M, Stupp R, Reifenberger G, Brandes AA, van den Bent MJ, Wick W, Hegi ME MGMT promoter methylation in malignant gliomas: ready for personalized medicine? Nat Rev Neurol. 2009 Dec 8. [Epub ahead of print] |
| Küsters-Vandevelde HV, Klaasen A, Küsters B, Groenen PJ, van Engen-van Grunsven IA, van Dijk MR, Reifenberger G, Wesseling P, Blokx WA. Activating mutations of the GNAQ gene: a frequent event in primary melanocytic neoplasms of the central nervous system. Acta Neuropathol. 2009 Nov 22. [Epub ahead of print] |
| Barski D, Wolter M, Reifenberger G, Riemenschneider MJ. Hypermethylation and Transcriptional Downregulation of the TIMP3 Gene Is Associated with Allelic Loss on 22q12.3 and Malignancy in Meningiomas. Brain Pathol. 2009 Oct 6. [Epub ahead of print] |
| Wick W, Hartmann C, Engel C, Stoffels M, Felsberg J, Stockhammer F, Sabel MC, Koeppen S, Ketter R, Meyermann R, Rapp M, Meisner C, Kortmann RD, Pietsch T, Wiestler OD, Ernemann U, Bamberg M, Reifenberger G, von Deimling A, Weller M. NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with procarbazine, lomustine, and vincristine or temozolomide. J Clin Oncol. 2009 Dec 10;27(35):5874-80. |
| Felsberg J, Rapp M, Loeser S, Fimmers R, Stummer W, Goeppert M, Steiger HJ, Friedensdorf B, Reifenberger G, Sabel MC. Prognostic significance of molecular markers and extent of resection in primary glioblastoma patients. Clin Cancer Res. 2009 Nov 1;15(21):6683-93. |
| Ernst A, Hofmann S, Ahmadi R, Becker N, Korshunov A, Engel F, Hartmann C, Felsberg J, Sabel M, Peterziel H, Durchdewald M, Hess J, Barbus S, Campos B, Starzinski-Powitz A, Unterberg A, Reifenberger G, Lichter P, Herold-Mende C, Radlwimmer B Genomic and expression profiling of glioblastoma stem cell-like spheroid cultures identifies novel tumor-relevant genes associated with survival. Clin Cancer Res. 2009 Nov 1;15(21):6541-50. |
| Götze S, Wolter M, Reifenberger G, Müller O, Sievers S. Frequent promoter hypermethylation of Wnt pathway inhibitor genes in malignant astrocytic gliomas. Int J Cancer. 2009 Oct 21. [Epub ahead of print]. |
| Kurzwelly D, Glas M, Roth P, Weimann E, Lohner H, Waha A, Schabet M, Reifenberger G, Weller M, Herrlinger U. Primary CNS lymphoma in the elderly: temozolomide therapy and MGMT status. J Neurooncol. 2009 Oct 20. [Epub ahead of print] |
| Grzendowski M, Riemenschneider MJ, Hawranke E, Stefanski A, Meyer HE, Reifenberger G, Stühler K. Simultaneous extraction of nucleic acids and proteins from tissue specimens by ultracentrifugation: A protocol using the high-salt protein fraction for quantitative proteome analysis. Proteomics. 2009 Nov;9(21):4985-90. |
| Weller M, Felsberg J, Hartmann C, Berger H, Steinbach JP, Schramm J, Westphal M, Schackert G, Simon M, Tonn JC, Heese O, Krex D, Nikkhah G, Pietsch T, Wiestler O, Reifenberger G, von Deimling A, Loeffler M. Molecular predictors of progression-free and overall survival in patients with newly diagnosed glioblastoma: a prospective translational study of the german glioma network. J Clin Oncol. 2009 Dec 1;27(34):5743-50. |
| Malzkorn B, Wolter M, Liesenberg F, Grzendowski M, Stühler K, Meyer HE, Reifenberger G. Identification and Functional Characterization of microRNAs Involved in the Malignant Progression of Gliomas. Brain Pathol. 2009 Aug 19. [Epub ahead of print] |
| Riemenschneider MJ, Reifenberger G. Novel insights into the pathogenesis of gliomas based on large-scale molecular profiling approaches. Curr Opin Neurol. 2009 Sep 5. [Epub ahead of print]. |
| Pauleit D, Stoffels G, Bachofner A, Floeth FW, Sabel M, Herzog H, Tellmann L, Jansen P, Reifenberger G, Hamacher K, Coenen HH, Langen KJ. Comparison of (18)F-FET and (18)F-FDG PET in brain tumors. Nucl Med Biol. 2009 Oct;36(7):779-87. |
| Riemenschneider MJ, Beseoglu K, Hänggi D, Reifenberger G. Prostate adenocarcinoma metastasis in the pituitary gland. Arch Neurol. 2009 Aug;66(8):1036-7. |
| Hartmann C, Meyer J, Balss J, Capper D, Mueller W, Christians A, Felsberg J, Wolter M, Mawrin C, Wick W, Weller M, Herold-Mende C, Unterberg A, Jeuken JW, Wesseling P, Reifenberger G, von Deimling A. Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas. Acta Neuropathol. 2009 Oct;118(4):469-74. |
| Riemenschneider MJ, Reifenberger G. Molecular neuropathology of gliomas. Int J Mol Sci. 2009 Jan;10(1):184-212. |
| Riemenschneider MJ, Reifenberger G. Astrocytic tumors. Recent Results. Cancer Res. 2009;171:3-24. |
| Warnke C, Lanzman RS, Klink B, Schellhammer F, Reifenberger G, Methner A. Diffuse leptomeningeal astrocytoma in a patient with infantile epilepsy. Arch Neurol. 2009 Mar;66(3):408-9. |
| Scholz M, Hoischen A, Radlwimmer B, Weber RG, Harders A, Reifenberger G, Riemenschneider MJ. Rosetted glioneuronal tumor of the spine with overtly anaplastic histological features. Acta Neuropathol. 2009 May;117(5):591-3. |
| Pfister S, Remke M, Benner A, Mendrzyk F, Toedt G, Felsberg J, Wittmann A, Devens F, Gerber NU, Joos S, Kulozik A, Reifenberger G, Rutkowski S, Wiestler OD, Radlwimmer B, Scheurlen W, Lichter P, Korshunov A. Outcome prediction in pediatric medulloblastoma based on DNA copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN loci. J Clin Oncol. 2009 Apr 1;27(10):1627-36. |
| Glas M, Happold C, Rieger J, Wiewrodt D, Bähr O, Steinbach JP, Wick W, Kortmann RD, Reifenberger G, Weller M, Herrlinger U. Long-term survival of patients with glioblastoma treated with radiotherapy and lomustine plus temozolomide. J Clin Oncol. 2009 Mar 10;27(8):1257-61. |
| Koga T, Morita A, Maruyama K, Tanaka M, Ino Y, Shibahara J, Louis DN, Reifenberger G, Itami J, Hara R, Saito N, Todo T. Long-term control of disseminated pleomorphic xanthoastrocytoma with anaplastic features by means of stereotactic irradiation. Neuro Oncol. 2009 Aug;11(4):446-51. |
| Waha A, Felsberg J, Hartmann W, von dem Knesebeck A, Mikeska T, Joos S, Wolter M, Koch A, Yan P, Endl E, Wiestler O, Reifenberger G, Pietsch T. DUSP4/MKP-2 is epigenetically regulated and acts as a growth suppressor in glioma cells. Cancer Res accepted. |
| 2005 |
| Originalarbeiten |
| Lamszus K, Brockmann MA, Eckerich C, Bohlen P, May C, Mangold U, Fillbrandt R, Westphal M. Inhibition of glioblastoma angiogenesis and invasion by combined treatments directed against vascular endothelial growth factor receptor-2, epidermal growth factor receptor, and vascular endothelial-cadherin. Clin Cancer Res. 2005 Jul |
| Heese O, Disko A, Zirkel D, Westphal M, Lamszus K. Neural stem cell migration towards gliomas in vitro. Neuro-Oncology. 2005 Sept |
| Ekman M, Westphal M Cost of brain tumour in Europe. Eur J Neurol 2005;1:45-49 |
| Kim EL, Yoshizato K, Kluwe L, Meissner H, Warnecke G, Zapf S, Westphal M, Deppert W, Giese A Comparative assessment of the functional p53 status in glioma cells. Anticancer Res 2005;25:213-224 |
| Übersichtsartikel |
| Buchkapitel |
| 2006 |
| Originalarbeiten |
| Eckerich C, Zapf S, Ulbricht U, Muller S, Fillbrandt R, Westphal M, Lamszus K Contactin is expressed in human astrocytic gliomas and mediates repulsive effects. Glia 2006;53:1-12 |
| Goebell E, Fiehler J, Ding XQ, Paustenbach S, Nietz S, Heese O, Kucinski T, Hagel C, Westphal M, Zeumer H Disarrangement of fiber tracts and decline of neuronal density correlate in glioma patients--a combined diffusion tensor imaging and 1H-MR spectroscopy study. Am J Neuroradiol 2006;27:1426-1431 |
| Goebell E, Paustenbach S, Vaeterlein O, Ding XQ, Heese O, Fiehler J, Kucinski T, Hagel C, Westphal M, Zeumer H Low-grade and anaplastic gliomas: differences in architecture evaluated with diffusion-tensor MR imaging. Radiology 2006;239:217-22 |
| Grzelinski M, Urban-Klein B, Martens T, Lamszus K, Bakowsky U, Hobel S, Czubayko F, Aigner A RNA interference-mediated gene silencing of pleiotrophin through polyethylenimine-complexed small interfering RNAs in vivo exerts antitumoral effects in glioblastoma xenografts. Hum Gene Ther 2006;17:751-766 |
| Martens T, Schmidt NO, Eckerich C, Fillbrandt R, Merchant M, Schwall R, Westphal M, Lamszus K A novel one-armed anti-c-Met antibody inhibits glioblastoma growth In vivo. Clin Cancer Res 2006;12:6144-6152 |
| Ulbricht U, Eckerich C, Fillbrandt R, Westphal M, Lamszus K RNA interference targeting protein tyrosine phosphatase zeta/receptor-type protein tyrosine phosphatase beta suppresses glioblastoma growth in vitro and in vivo. J Neurochem 2006;98:1497-1506 |
| Westphal M, Ram Z, Riddle V, Hilt D, Bortey E; On behalf of the Executive Committee of the Gliadel Study Group Gliadel wafer in initial surgery for malignant glioma: long-term follow-up of a multicenter controlled trial. Acta Neurochir 2006;148:269-275 |
| Übersichtsartikel |
| Buchkapitel |
| 2007 |
| Originalarbeiten |
| The German Glioma Network, Weller M, Berger H, Hartmann C, Schramm J, Westphal M, Simon M, Goldbrunner R, Krex D, Steinbach JP, Ostertag CB, Loeffler M, Pietsch T, von Deimling A. Combined 1p/19q Loss in Oligodendroglial Tumors: Predictive or Prognostic Biomarker? Clin Cancer Res. 2007 Dec 1;13(23):6933-6937. |
| Günther HS, Schmidt NO, Phillips HS, Kemming D, Kharbanda S, Soriano R, Modrusan Z, Meissner H, Westphal M, Lamszus K. Glioblastoma-derived stem cell-enriched cultures form distinct subgroups according to molecular and phenotypic criteria. Oncogene. 2007 Nov 26. |
| Hansen K, Wagner B, Hamel W, Schweizer M, Haag F, Westphal M, Lamszus K. Autophagic cell death induced by TrkA receptor activation in human glioblastoma cells. J Neurochem. 2007 Oct;103(1):259-75. Epub 2007 Jul 17. |
| Eckerich C, Zapf S, Fillbrandt R, Loges S, Westphal M, Lamszus K. Autophagic cell death induced by TrkA receptor activation in human glioblastoma cells. Int J Cancer. 2007 Jul 15;121(2):276-83 |
| 2005 |
| Originalarbeiten |
| Schichor C, Kerkau S, Visted T, Martini R, Bjerkvig R, Tonn JC, Goldbrunner R. The brain slice chamber, a novel variation of the Boyden Chamber Assay, allows time-dependent quantification of glioma invasion into mammalian brain in vitro. J Neurooncol. 2005;73(1):9-18 |
| Popperl G, Goldbrunner R, Gildehaus FJ, Kreth FW, Tanner P, Holtmannspotter M, Tonn JC, Tatsch K. O-(2-[18F]fluoroethyl)-l-tyrosine PET for monitoring the effects of convection-enhanced delivery of paclitaxel in patients with recurrent glioblastoma. Eur J Nucl Med Mol Imaging. 2005 May 5; |
| Rachinger W, Goetz C, Poepperl G, Gildehaus FJ, Kreth FW, Holtmannspotter M, Herms J, Koch W, Tatsch K, Tonn JC. Positron emission tomography with O-(2-[18F]fluoroethyl)-l-tyrosine versus magnetic resonance imaging in the diagnosis of recurrent gliomas. Neurosurgery. 2005 Sep;57(3):505-11 |
| Goetz C, Rachinger W, Decker M, Gildehaus FJ, Stocker S, Jung G, Tatsch K, Reulen HJ, Tonn JC Distribution of labelled anti-tenascin antibodies and fragments after injection into intact or partly resected C6-gliomas in rats. Cancer Immunol Immunother 2005;54:337-344 |
| Muacevic A, Peller M, Ruprecht L, Berg D, Fend L, Sroka R, Reulen HJ, Reiser M, Tonn JC, Kreth FW Image guided interstitial laser thermotherapy: a canine model evaluated by magnetic resonance imaging and quantitative autoradiography. Acta Neurochir 2005;147:175-185 |
| Übersichtsartikel |
| Buchkapitel |
| 2006 |
| Originalarbeiten |
| Culmsee C, Gasser E, Hansen S, Tonn JC, Wagner E, Goldbrunner R Effects of Raf-1 siRNA on human cerebral microvascular endothelial cells: a potential therapeutic strategy for inhibition of tumor angiogenesis. Brain Res in press |
| Grau S, Trillsch F, Herms J, Thon N, Nelson PJ, Tonn JC, Goldbrunner R Expression of VEGFR3 in glioma endothelium correlates with tumor grade. J Neurooncol in press |
| Kreth FW, Faist M, Grau S, Ostertag CB Interstitial 125I radiosurgery of supratentorial de novo WHO Grade 2 astrocytoma and oligoastrocytoma in adults: long-term results and prognostic factors. Cancer 2006;106:1372-1381 |
| Miebach S, Grau S, Hummel V, Rieckmann P, Tonn JC, Goldbrunner R Isolation and culture of microvascular endothelial cells from gliomas of different WHO grades. J Neurooncol 2006;76:39-48 |
| Muacevic A, Staehler M, Drexler C, Wowra B, Reiser M, Tonn JC Technical description, phantom accuracy and clinical feasibility for fiducial-free frameless real-time image-guided spinal radiosurgery. J Neurosurg 2006;5:303-312 |
| Peraud A, Goetz C, Siefert A, Tonn JC, Kreth FW Interstitial Iodine-125 radiosurgery alone or in combination with microsurgery for pediatric patients with eloquently located low grade glioma: a pilot study. Childs Nervous System in press |
| Poepperl G, Goetz C, Rachinger W, Schnell O, Gildehaus FJ, Tonn JC, Tatsch K Serial O-(2-[(18)F]fluoroethyl)-L: -tyrosine PET for monitoring the effects of intracavitary radioimmunotherapy in patients with malignant glioma. Eur J Nucl Med Mol Imaging 2006;33:792-800 |
| Schichor C, Birnbaum T, Etminan N, Schnell O, Grau S, Miebach S, Aboody K, Padovan C, Straube A, Tonn JC, Goldbrunner R Vascular endothelial growth factor A contributes to glioma-induced migration of human marrow stromal cells (hMSC). Exp Neurol 2006;199:301-310 |
| Stummer W, Pichlmeier U, Meinel T, Wiestler OD, Zanella F, Reulen HJ; ALA-Glioma Study Group Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. Lancet Oncol 2006;7:392-401 |
| 2007 |
| Originalarbeiten |
| Grau S, Trillsch F, Herms J, Thon N, Nelson P, Tonn JC, Goldbrunner RH Expression of vascular endothelial growth factor receptor 3 in gliomas correlates with tumour grade. J Neurooncol (2007) 82: 491-500 |
| Tanner P, Holtmannspötter M, Tonn JC, Goldbrunner R Effects of drug efflux on convection enhanced paclitaxel delivery to malignant gliomas. Neurosurgery (2007) 880-882 |
| Zelenkov P, Baumgartner R, Bise K, Heide M, Meier R, Stocker S, Sroka R, Goldbrunner RH, Stummer W Acute morphological sequelae of photodynamic therapy with 5-aminolevulinic acid in the C6 spheroid model. J Neurooncol. (2007) 82:49-60 |
| Birnbaum T, Roider J, Schankin CJ, Padovan CS, Schichor C, Goldbrunner RH, Straube A Malignant gliomas actively recruit bone marrow stem cells by secreting angiogenic cytokines. J Neurooncol (2007) 83:241-247 |
| Schankin C, Ferrari U, Reinisch VM, Birnbaum T, Goldbrunner RH, Straube A Characteristics of Brain Tumor-Associated Headache. Cephalalgia (2007), 27:904-911. |
| Weller M, Berger H, Hartmann C, Schramm J, Westphal M, Simon M, Goldbrunner R, Krex D, Steinbach JP, Ostertag CB, Löffler M, Pietsch T, Pietsch T, von Deimling A; German Glioma Network. Combined 1p/19q loss in oligodendroglial tumors: predictive or prognostic biomarker? Clin Cancer Res. (2007), 13(23):6933-6937. |
| Pöpperl G, Kreth FW, Mehrkens JH, Herms J, Seelos K, Koch W, Gildehaus FJ, Kretzschmar HA, Tonn JC, Tatsch K. FET PET for the evaluation of untreated gliomas: correlation of FET uptake and uptake kinetics with tumour grading. Eur J Nucl Med Mol Imaging. 2007 Dec;34(12):1933-42. Epub 2007 Sep 1 |
| Stepp H, Beck T, Pongratz T, Meinel T, Kreth FW, Tonn JCh, Stummer W. ALA and malignant glioma: fluorescence-guided resection and photodynamic treatment. J Environ Pathol Toxicol Oncol. 2007;26(2):157-64. |
| Grau S, Trillsch F, Herms J, Thon N, Nelson P, Tonn JC, Goldbrunner RH Expression of vascular endothelial growth factor receptor 3 in gliomas correlates with tumour grade. J Neurooncol (2007) 82: 491-500 |
| Grasbon-Frodl EM, Kreth FW, Ruiter M, Schnell O, Bise K, Felsberg J, Reifenberger G, Tonn JC, Kretzschmar HA. Intratumoral homogeneity of MGMT promoter hypermethylation as demonstrated in serial stereotactic specimens from anaplastic astrocytomas and glioblastomas. Int J Cancer. 2007 Dec 1;121(11):2458-64. |
| Beck TJ, Kreth FW, Beyer W, Mehrkens JH, Obermeier A, Stepp H, Stummer W, Baumgartner R. Interstitial photodynamic therapy of nonresectable malignant glioma recurrences using 5-aminolevulinic acid induced protoporphyrin IX. Lasers Surg Med. 2007 Jun;39(5):386-93. |
| 2008 |
| Originalarbeiten |
| Schnell O, Krebs B, Wagner E, Romagna A, Beer AJ, Grau S, Thon N, Goetz C, Kretzschmar HA, Tonn, JC, Goldbrunner R Expression of integrin αvβ3 in gliomas correlates with tumor grade and is not restricted to tumor vasculature. Brain Pathol (2008) 18:378-386 0 |
| Grau S, Trillsch F, Teichert-von Lüttichau I, Nelson P, Herms J, Tonn JC, Goldbrunner R Lymphatic phenotype of tumor vessels in malignant gliomas. Neuropathol Appl Neurobiol (2008) 34:675-679 |
| Thon N, Damianoff K, Hegermann J, Grau S, Krebs B, Tonn JC, Goldbrunner R. Presence of pluripotent CD133+ cells correlates with malignancy of gliomas. Mol Cell Neurosci (2008) in press |
| Tichomirova M, Theodoropoulou M, Daly AF, Yassouridis A, Hansen S, Lu J, Lange M, Goldbrunner R, Stalla G, Renner U Toll like receptor-4 is expressed in meningiomas and mediates the antiproliferative action of paclitaxel. Int J Cancer (2008) 123:1956-1963 |
| Schichor C, Witte J, Schöller K, Tanner P, Uhl E, Goldbrunner R, Tonn JC Magnetically guided neuronavigation of flexible instruments in shunt placement, transsphenoidal procedures and craniotomies. Neurosurgery (2008) 63 (1 suppl 1):121-128 |
| Schnell O, Schöller K, Ruge M, Siefert A, Tonn JC, Kreth FW. Surgical resection plus stereotactic (125)I brachytherapy in adult patients with eloquently located supratentorial WHO grade II glioma - Feasibility and outcome of a combined local treatment concept. J Neurol. 2008 Oct;255(10):1495-502. Epub 2008 Jul 25. |
| Mehrkens JH, Pöpperl G, Rachinger W, Herms J, Seelos K, Tatsch K, Tonn JC, Kreth FW. The positive predictive value of O-(2-[18F]fluoroethyl)-L-tyrosine (FET) PET in the diagnosis of a glioma recurrence after multimodal treatment. J Neurooncol. 2008 May;88(1):27-35. Epub 2008 Jan |
| Stummer W, Beck T, Beyer W, Mehrkens JH, Obermeier A, Etminan N, Stepp H, Tonn JC, Baumgartner R, Herms J, Kreth FW. Long-sustaining response in a patient with non-resectable, distant recurrence of glioblastoma multiforme treated by interstitial photodynamic therapy using 5-ALA: case report. J Neurooncol. 2008 Mar;87(1):103-9. Epub 2007 Nov 23 |
| Wowra B, Zausinger S, Drexler C, Kufeld M, Muacevic A, Staehler M, Tonn JC. CyberKnife radiosurgery for malignant spinal tumors: characterization of well-suited patients. Spine. 2008 Dec 15;33(26):2929-34. |
| 2009 |
| Originalarbeiten |
| Schnell O, Krebs B, Carlsen J, Miederer I, Goetz C, Goldbrunner R, Wester HJ, Haubner R, Pöpperl G, Holtmannspötter M, Kretzschmar H, Kessler H, Tonn JC, Schwaiger M, Beer A. Imaging of integrin alpha-v-beta-3 expression in patients with malignant glioma by [18F]Galacto-RGD Positron Emission Tomography. Neuro Oncol. 2009 Dec;11(6):861-70. Epub .PMID: 19401596 [PubMed - in process] |
| Wowra B, Muacevic A, Tonn JC. Quality of radiosurgery for single brain metastases with respect to treatment technology: a matched-pair analysis. J Neurooncol. 2009 Aug;94(1):69-77. Epub 2009 Feb 1.PMID: 19184641 [PubMed - indexed for MEDLINE] |
| Weller M, Felsberg J, Hartmann C, Berger H, Steinbach JP, Schramm J, Westphal M, Schackert G, Simon M, Tonn JC, Heese O, Krex D, Nikkhah G, Pietsch T, Wiestler O, Reifenberger G, von Deimling A, Loeffler M. Molecular predictors of progression-free and overall survival in patients with newly diagnosed glioblastoma: a prospective translational study of the German Glioma Network. J Clin Oncol. 2009 Dec 1;27(34):5743-50. Epub 2009 Oct 5.PMID: 19805672 [PubMed - indexed for MEDLINE] |
| Thon N, Eigenbrod S, Grasbon-Frodl EM, Ruiter M, Mehrkens JH, Kreth S, Tonn JC, Kretzschmar HA, Kreth FW. Novel molecular stereotactic biopsy procedures reveal intratumoral homogeneity of loss of heterozygosity of 1p/19q and TP53 mutations in World Health Organization grade II gliomas. J Neuropathol Exp Neurol. 2009 Nov;68(11):1219-28.PMID: 19816195 [PubMed - indexed for MEDLINE] |
| Røsland GV, Svendsen A, Torsvik A, Sobala E, McCormack E, Immervoll H, Mysliwietz J, Tonn JC, Goldbrunner R, Lønning PE, Bjerkvig R, Schichor C. Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation. Cancer Res. 2009 Jul 1;69(13):5331-9. Epub 2009 Jun 9.PMID: 19509230 [PubMed - indexed for MEDLINE] |
| Rachinger W, Grau S, Holtmannspötter M, Herms J, Tonn JC, Kreth FW. Serial stereotactic biopsy of brainstem lesions in adults improves diagnostic accuracy compared with MRI only. J Neurol Neurosurg Psychiatry. 2009 Oct;80(10):1134-9. Epub 2009 Jun 10.PMID: 19520698 [PubMed - indexed for MEDLINE] |
| Wowra B, Muacevic A, Zausinger S, Tonn JC. Radiosurgery for spinal malignant tumors Dtsch Arztebl Int. 2009 Feb;106(7):106-12. Epub 2009 Feb 13. Review.PMID: 19562022 [PubMed - indexed for MEDLINE] E] |
| 2005 |
| Originalarbeiten |
| Herrlinger U, Rieger J, Steinbach JP, Nägele T, Dichgans J, Weller M. UKT-04 trial of continuous metronomic low-dose chemotherapy with methotrexate and cyclophosphamide for recurrent glioblastoma. J Neuro-Oncol 2005;71:295-9 |
| Duffner F, Ritz R, Freudenstein D, Weller M, Dietz K, Wessels J. Specific intensity imaging for glioblastoma and neural cell cultures with 5-aminolevulinic acid-derived protoporphyrin IX. J Neuro-Oncol 2005;71:107-111 |
| Steinbach JP, Wolburg H, Klumpp A, Weller M. Hypoxia sensitizes human malignant glioma cells towards CD95L-induced cell death. J Neurochem 2005;92:1340-1349 |
| Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJB, Belanger K, Brandes AA, Cairncross JG, Marosi C, Bogdahn U, Curschmann J, Janzer RC, Ludwin S, Gorlia T, Allgeier A, Lacombe D, Eisenhauer E, Mirimanoff RO, on behalf of the European Organisation for Research and Treatment of Cancer (EORTC) Brain Tumor and Radiotherapy Groups and National Cancer Institute of Canada Clinical Trials Group (NCIC CTG). Radiotherapy plus concomitant and adjuvant temozolomide for patients with newly diagnosed glioblastoma. N Engl J Med 2005;352:987-996 |
| Hegi ME, Diserens AC, Gorlia T, Hamou MF, de Tribolet N, Weller M, Kros JM, Hainfellner JA, Mason WP, Mariani L, Bromberg JEC, Hau P, Mirimanoff RO, Cairncross G, Janzer R, Stupp R. MGMT gene silencing and response to temozolomide in glioblastoma. N Engl J Med 2005;352:997-1003 |
| Uhl M, Weiler M, Wick W, Jacobs AH, Weller M, Herrlinger U. Migratory neural stem cells for improved thymidine kinase-based gene therapy of malignant gliomas. Biochem Biophys Res Commun 2005;328:125-129 |
| Wischhusen J, Schneider D, Mittelbronn M, Meyermann R, Engelmann H, Jung G, Wiendl H, Weller M. Death receptor-mediated apoptosis in human malignant glioma cells: modulation by the CD40/CD40L system. J Neuroimmunol 2005;162:28-42 |
| Eyüpoglu IY, Hahnen E, Buslei R, Siebzehnrübl FA, Savaskan NE, Lüders M, Christian Tränkle C, Wick W, Weller M, Fahlbusch R, Blümcke I. Suberoylanilide hydroxamic acid (SAHA) has potent anti-glioma properties in vitro, ex vivo and in vivo. J Neurochem 2005;93:992-999 |
| Wick W, Weller M. How lymphotoxic is dose-intensified temozolomide? The glioblastoma experience. J Clin Oncol 2005;23:4235-4236 |
| Wischhusen J, Friese M, Mittelbronn M, Meyermann R, Weller M. HLA-E protects glioma cells from NKG2D-mediated immune responses in vitro: implications for immune escape in vivo. J Neuropathol Exp Neurol 2005;64:523-528 |
| Amatya VJ, Naumann U, Weller M, Ohgaki H. TP53 promoter methylation in human gliomas. Acta Neuropathol 2005;110:178-184 |
| Tabatabai G, Bähr O, Möhle R, Eyüpoglu IY, Böhmler AM, Wischhusen J, Rieger J, Blümcke I, Weller M, Wick W. Lessons from the bone marrow: how malignant glioma cells attract adult hematopoietic progenitor cells. Brain 2005;128:2200-2211 |
| Grosse-Hovest L, Wick W, Minoia R, Weller M, Rammensee HG, Brem G, Jung G Supraagonistic, bispecific single-chain antibody purified from the serum of cloned, transgenic cows induces T-cell-mediated killing of glioblastoma cells in vitro and in vivo. Int J Cancer 2005;117:1060-1064 |
| Mittelbronn M, Wolff M, Bultmann E, Nagele T, Capper D, Beck R, Meyermann R, Beschorner R Disseminating anaplastic brainstem oligodendroglioma associated with allelic loss in the tumor suppressor candidate region D19S246 of chromosome 19 mimicking an inflammatory central nervous system disease in a 9-year-old boy. Human Pathol 2005;36:854-857 |
| Ritz R, Müller M, Weller M, Dietz K, Kuci S, Roser F, Tatagiba M Hypericin: a promising fluorescence marker for differentiating between glioblastoma and neurons in vitro. Int J Oncol 2005;27:1543-1549 |
| Timmermann B, Kortmann RD, Kühl J, Rutkowski S, Dieckmann K, Meisner C, Bamberg M Role of radiotherapy in anaplastic ependymoma in children under age of 3 years: Results of the prospective German brain tumor trials HIT-SKK 87 and 92. Radiother Oncol 2005;77:278-285 |
| Übersichtsartikel |
| Buchkapitel |
| Weller M.: Gliomas. In Kettenmann H, Ransom BR (Hrsg.) Neuroglia. Oxford University Press, New York, NY, 2005, 521-531 |
| 2006 |
| Originalarbeiten |
| Aulwurm S, Wischhusen J, Friese M, Borst B, Weller M Immune stimulatory effects of CD70 override CD70-mediated immune cell apoptosis in rodent glioma models and confer long-lasting anti-glioma immunity in vivo. Int J Cancer 2006;118:1728-1735 |
| Eisele G, Wischhusen J, Mittelbronn M, Meyermann R, Waldhauer I, Steinle A, Weller M, Friese MA TGF-b and metalloproteinases differentially suppress NKG2D ligand surface expression on malignant glioma cells. Brain 2006;129:2416-2425 |
| Hermisson M, Klumpp A, Wick W, Wischhusen J, Nagel G, Roos W, Kaina B, Weller M O6-methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells. J Neurochem 2006;96:766-776 |
| Herrlinger U, Rieger J, Koch D, Loeser S, Blaschke B, Kortmann RD, Steinbach JP, Hundsberger T, Wick W, Meyermann R, Tan TC, Sommer C, Bamberg M, Reifenberger R, Weller M UKT-03 phase II trial of CCNU plus temozolomide chemotherapy in addition to radiotherapy in newly diagnosed glioblastoma. J Clin Oncol 2006;24:4412-4417 |
| Mittelbronn N, Capper D, Bunz B, Dietz K, Goeppert B, Ajaaj R, Tabatabai T, Stubenvoll F, Schlaszus H, Merseburger AS, Becker R, Freudenstein D, Wick W, Weller M, Meyermann R, Simon P De novo erythropoietin receptor (EPO-R) expression in human neoplastic glial cells decreases with grade of malignancy but is favourably associated with patient survival. Neuropathol Appl Neurobiol in press |
| Mittelbronn M, Schittenhelm J, Lemke D, Ritz R, Nägele T, Weller M, Meyermann R, Beschorner R Low grade ganglioglioma rapidly progressing to a WHO grade IV tumor showing malignant transformation in both astroglial and neuronal cell components. Neuropathology in press |
| Naumann U, Bähr O, Wolburg W, Altenberend S, Wick W, Liston P, Ashkenazi A, Weller M Adenoviral expression of XIAP antisense RNA induces apoptosis in glioma cells and suppresses the growth of xenografts in nude mice. Gene Therapy in press |
| Naumann U, Huang H, Wolburg H, Wischhusen J, Weit S, Ohgaki H, Weller M PCTAIRE3: a putative mediator of growth arrest and death induced by CTS-1, a dominant-positive p53-derived synthetic tumor suppressor, in human malignant glioma cells. Cancer Gene Ther 2006;13:469-478 |
| Roos WP, Batista LFZ, Naumann SC, Wick W, Weller M, Menck CFM, Kaina B Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methyluanine. Oncogene in press |
| Roth P, Aulwurm S, Gekel I, Beier D, Sperry RG, Mittelbronn M, Meyermann R, Beaman KD, Weller M, Wischhusen J Regeneration and tolerance factor (RTF): a novel mediator of glioblastoma-associated immunosuppression. Cancer Res 2006;66:3852-3858 |
| Scheel B, Aulwurm S, Probst J, Hoerr I, Rammensee HG, Weller M, Pascolo S Therapeutic anti-tumor immunity triggered by injections of immunostimulating single-stranded RNA. Eur J Immunol 2006;36:2807-2816 |
| Schittenhelm J, Erdmann T, Maennlin S, Will BE, Beschorner R, Bornemann A, Meyermann R, Mittelbronn M Gliosarcoma with chondroid and osseous differentiation. Neuropathology in press |
| Schmidt F, Fischer J, Herrlinger U, Dietz K, Dichgans J, Weller M PCV chemotherapy for recurrent glioblastoma. Neurology 2006;66:587-589 |
| Steinbach JP, Blaicher HP, Herrlinger U, Wick W, Nägele T, Meyermann R, Tatagiba M, Bamberg M, Dichgans J, Karnath HO, Weller M Surviving glioblastoma for more than 5 years: the patients´ perspective. Neurology 2006;66:239-242 |
| Tabatabai G, Frank B, Möhle R, Weller M, Wick W Irradiation and hypoxia promote homing of hematopoietic progenitor cells towards gliomas by TGF-b-dependent HIF-1a-mediated induction of CXCL12. Brain 2006;129:2426-2435 |
| Tabatabai G, Frank B, Wick A, Lemke D, Von Kürthy G, Obermüller U, Heckl S, Christ G, Weller M, Wick W Synergistic antiglioma activity of radiotherapy and enzastaurin. Ann Neurol in press |
| Tran TT, Uhl M, Ma JY, Janssen L, Sriram V, Aulwurm S, Kerr I, Lam A, Webb HK, Kapoun AM, Kizer DE, McEnroe G, Hart B, Axon J, murphy A, Chakravarty S, Dugar S, Protter AA, Higgins LS, Wick W, Weller M, Wong DH Inhibiting TGF-ß signaling restores immune surveillance in the SMA-560 glioma model. Neurooncology in press |
| Warth A, Mittelbronn M, Hülper P, Erdlenbruch B, Wolburg H Expression of the water channel protein aquaporin-9 in malignant brain tumors. Appl Immunohistochem Mol Morph in press |
| Warth A, Simon P, Capper D, Goeppert B, Tabatabai G, Herzog H, Dietz K, Stubenvoll F, Ajaaj R, Becker R, Weller M, Meyermann R, Wolburg H, Mittelbronn M Expression pattern of the water channel aquaporin-4 in human gliomas is associated with blood-brain barrier disturbance but not with patient survival. J Neurosci Res in press |
| Weiler M, Bähr O, Hohlweg U, Naumann U, Rieger J, Huang H, Tabatabai G, Krell HW, Ohgaki H, Weller M, Wick W BCL-x(L): time-dependent dissociation between modulation of apoptosis and invasiveness in human malignant glioma cells. Cell Death Differ 2006;13:1156-1169 |
| Übersichtsartikel |
| Buchkapitel |